OVEREXPRESSION OF MELANOCORTIN 2 RECEPTOR ACCESSORY PROTEIN 2 (MRAP2) IN ADULT PARAVENTRICULAR MC4R NEURONS REGULATES ENERGY INTAKE AND EXPENDITURE

Overexpression of melanocortin 2 receptor accessory protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditure

Objective: Melanocortin 2 receptor accessory protein 2 (MRAP2) has a critical role in energy homeostasis.Although MRAP2 has been shown to regulates a number of GPCRs involved in metabolism, the key neurons responsible for the Pentair EasyTouch Parts phenotype of gross obesity in MRAP2 deficient animals are unclear.Furthermore, to date, all the muri

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Delayed administration of high dose human immunoglobulin G enhances recovery after traumatic cervical spinal cord injury by modulation of neuroinflammation and protection of the blood spinal cord barrier

Background/introduction: The neuroinflammatory response plays a major role in the secondary injury cascade after traumatic spinal cord injury (SCI).To date, systemic anti-inflammatory medications such as methylprednisolone sodium succinate (MPSS) have shown promise in SCI.However, systemic immunosuppression can have detrimental side effects.Therefo

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What Are You Tinking About Where? Syntactic Ambiguity between Abstract Arguments and Concrete Adjuncts in Hungarian, Modulated by Concreteness

Background.Te critical importance of lexical concreteness and embodied sensorimotor processes for language comprehension is ofen assumed to be beyond doubt.Hungarian grammar is unique in that it expresses certain verb arguments using spatial sufxes, which sometimes create ambiguity between literal spatial adjuncts and abstract verb arguments.Object

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Actor/observer asymmetry in risky decision making

Are people willing to gamble more Alcoholic Drinks for themselves than what they deem reasonable for others? We addressed this question in a simplified computer gambling task in which subjects chose from a set of 10 cards.Subjects selected one card at a time after being instructed that 9 cards were good (win a dollar per card) and one was really ba

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